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Creators/Authors contains: "Dumett, Miguel"

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  1. ; ; (, Journal of Open Source Software)
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  2. ; ; ; ; ; ; ; ; (, Mathematics)
    Biological models for cardiac regeneration and remodeling, along with the effects of cytokines or chemokines during the therapy with mesenchymal stem cells after a myocardial infarction, are of crucial importance for understanding the complex underlying mechanisms. This paper presents a mathematical model composed of three coupled partial differential equations that describes the dynamics of stem cells, nutrients and chemokines, highlighting the fundamental role of the chemokines during the myocardial tissue regeneration process. The system is solved numerically using mimetic difference operators and the MOLE library for MATLAB. The results show the tissue regeneration process in the necrotic part closest to the cell implantation area. 
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  3. ; ; ; ; (, GEM - International Journal on Geomathematics)
    Abstract Mimetic finite difference operators$$\textbf{D}$$ D ,$$\textbf{G}$$ G are discrete analogs of the continuous divergence (div) and gradient (grad) operators. In the discrete sense, these discrete operators satisfy the same properties as those of their continuum counterparts. In particular, they satisfy a discrete extended Gauss’ divergence theorem. This paper investigates the higher-order quadratures associated with the fourth- and sixth- order mimetic finite difference operators, and show that they are indeed numerical quadratures and satisfy the divergence theorem. In addition, extensions to curvilinear coordinates are treated. Examples in one and two dimensions to illustrate numerical results are presented that confirm the validity of the theoretical findings. 
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